Custom Peptides
Cayman Chemical MetEnkephalInamIDtrIfluor 10mg
A peptide opioid receptor agonist; binds to opioid receptors in rat cerebellum homogenates (IC50 = 0.2 µM); reduces the twitch height in electrically stimulated isolated guinea pig ileum and isolated mouse vas deferens; induces analgesia in the hot plate and tail-flick tests in rats at 300 UG/animal
Cayman Chemical SynthetIc Curzeren 10mg
A sesquiterpene with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 3.36 UG/L with a synergistic effect when used in combination with eucalyptol; active against F. graminearum at 0.5 mg/ml; inhibits the proliferation of SK-MEL-19 melanoma cells (IC50 = 5.17 UG/ml), as well as AGP-01 gastric and HCT116 colon cancer cells (IC50s = 8.04 and 9.18 UG/ml, respectively) and MRC-5 non-cancerous human fibroblasts (IC50 = 11.45 UG/ml); induces apoptosis in, and decreases migration of, SK-MEL-19 cells at 5 and 10 µM; reduces tumor weight in an SPC-A1 mouse xenograft model at 135 mg/kg
Cayman Chemical GemIglIptIntartrate 10mg
A DPP-4 inhibitor (IC50 = 0.01 µM); selective for DPP-4 over DPP-8, DPP-9, and FAP- α (IC50s = 277.28, 233.72, 418.43 µM, respectively); inhibits DPP-4 activity in isolated human plasma (IC50 = 11.5 nM); scavenges methylglyoxal in vitro and inhibits AGE formation between BSA and methylglyoxal and cross-linking of AGE-BSA with rat tail tendon collagen (IC50s = 1.15, 11.69, and 1.39 mM, respectively); reduces the levels of circulating AGE and red blood cell IgG content in db/db diabetic mice at 100 mg/kg; decreases blood glucose and HbA1c levels and reduces pancreatic β-cell damage in a mouse model of STZ- and high-fat diet-induced diabetes; induces cytotoxicity in SW1736 and TPC-1 cells
Cayman Chemical PalustrIc AcId 10mg
A diterpenoid with diverse biological activities; increases secreted hydrogen peroxide levels in isolated mouse macrophages at 2 mg/ml; toxic to water fleas and rainbow trout (LC50s = 0.1 and 0.5 mg/L, respectively); phloem levels are increased in mechanically injured, as well as mechanically injured and L. abietinum-infected, red pine and white spruce trees; has been found as an environmental contaminant in pulp and paper mill effluent
Cayman Chemical Pralatrexate 10mg
A DHFR inhibitor (Ki = 13.4 pM) and antifolate; inhibits growth of acute lymphocytic leukemia cells (IC50 = 0.04 μM), MDA-468, SK-BR-3, and ZR-75-1 breast cancer cells (IC50s = 0.11, 0.28, and 0.26 μM, respectively), and SK-LC8 and SK-LC16 NSCLC cells (IC50s = 0.42 and 0.11 μM, respectively); increases median survival in vivo in an H9 T cell lymphoma mouse xenograft model
Cayman Chemical Ala1 3 11 15-EndothelIn-1 10mg
An ETB receptor agonist; selectively binds to ETB over ETA receptors (IC50s = 0.33 and 570 nM, respectively, for the porcine receptors); increases wound closure percentage in a scratch assay using HUVECs at 10 or 100 nM; increases body temperature in conscious rabbits at 0.15 or 0.3 nmol/kg; induces bronchoconstriction and increases mean arterial blood pressure in anesthetized guinea pigs at 20 nmol/kg, i.v.; has been used to determine the cross reactivity of monoclonal antibodies against endothelin in enzyme immunometric assays
Cayman Chemical TInptIn MetabolIte MC5 10mg
An active metabolite of tianeptine; selectively induces G protein activation in BRET assays using HEK293T cells expressing human MOR over human DOR (EC50s = 0.454 and >100 µM, respectively); decreases immobility in the forced swim test in wild-type mice, but not MOR knockout mice, indicating MOR-dependent antidepressant-like activity at 30 mg/kg
Cayman Chemical Dexamethason PalmItate 10mg
A prodrug form of dexamethasone; binds to the glucocorticoid receptor; reduces LPS-induced increases in cytokine levels in RAW 264.7 macrophages at 100 UG/ml in lipid nanoparticles; reduces paw inflammation and edema in a mouse model of collagen-induced rheumatoid arthritis at 1 mg/kg; inhibits VEGF-induced vascular hyperpermeability for up to nine months in rabbits at 1,280/animal as an intravitreal emulsion injection
Cayman Chemical Lnsoprazole sulfon NoxIde 10mg
A potential impurity found in commercial preparations of lansoprazole
Cayman Chemical DPPA 1trIfluoroacetAT s 10mg
An inhibitor of the PD-1-PD-L1 protein-protein interaction; binds to the extracellular domain of PD-L1 (Kd = 0.51 µM for the recombinant human protein); decreases tumor volume and improves survival in a CT26 murine colorectal cancer model at 2 mg/kg
Cayman Chemical ObtusIfolIn 10mg
An anthraquinone with diverse biological activities; prevents IL-1β-induced increases in NF-κB phosphorylation in chondrocytes at 25-200 µM; reduces cartilage degradation in a mouse model of DMM-induced osteoarthritis at 100 mg/kg; reduces blood glucose levels, as well as serum MDA, NO, triglyceride, and cholesterol levels, and increases serum SOD, GSH, and CAT activity at 30 and 90 mg/kg in a mouse model of STZ-induced diabetes
Cayman Chemical NdSmethyl DIltIazemhydroc 10mg
An active metabolite of diltiazem; binds to isolated rat cerebral cortex homogenates (IC50 = 323 nM); inhibits spontaneous contractions in isolated rat portal veins (IC50 = 489 nM); has been found as a contaminant in fresh water
Cayman Chemical N8AcetylspermIdInhydrochl 10mg
An endogenous polyamine; urinary levels are increased in patients with chronic pancreatitis; blood levels are increased in patients with ischemic cardiomyopathy, as well as in patients with Parkinson’s disease